The MATH+ Hospital Treatment Protocol for Covid-19 is a physiologic-based combination treatment regimen created by leaders in critical care medicine. All component medicines are FDA-approved, inexpensive, readily available and have been used for decades with well-established safety profiles.

As a group of colleagues with over 200 years of combined experience in Critical Care and Emergency Medicine, as well as long-standing shared interests in developing effective treatments for critical illnesses including sepsis, we formed a working group devoted to creating a treatment protocol against COVID-19. The protocol we devised, called “MATH+” is intended for use in the hospitalized patient, with an emphasis on early initiation — as soon as the patient develops a need for supplemental oxygen.

In the hospitals that have adopted the protocol and initiated it early in the treatment of patients, both state and medical center data reporting the mortality of COVID-19 patients treated in these hospitals compares strongly with COVID-19 mortality rates published in studies from around the world. Although these data are in evolution, the MATH+ hospitals have been reporting hospital mortality between 4% and 10% while the hospital mortality from published reports in the US, Italy, and China average approximately 23%.

The MATH+ Treatment Protocol can be downloaded here in several languages. For a detailed explanation of the efficacy of the Protocol please read our Scientific Review of COVID-19 and MATH+.